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17.7 Transfusion con veplate lak \rod.. the _carclivantular sys minimize te. efbects A blood lows ley 4) Reducing dhe volume of ty affecttcl lolood veniels 2) A& Hu production sf RBCs. & Sossing 19-30% 27 pallor /meobner do ssing mare Ham 30% =? sewere shock _Lfoho\) Restoring Blooel Volume -- When blo volume is So love Hid vill Lent to death From spel, ancl there wt ve time to ype brood ancl maphe tre oppo bloce! isn’t available, Hun ‘ood volume war ve. rentoreel. iwnmectiohthy - > Tu blood is coniist JF Probes amcl Cells suspendeol in w Salt solution . Loken we replace dort brood volume we replating Hu isotonic salk Studion. We efereal omer are: Normal saline or _cr_nulligee electrolyte solution thot winic tue electrolyte composition af plowma C for ex: Ringer's Solulion) - > Nolumne segacement only rearorea opie cicculodhion , ik doean’} veptore We 0, courying copanty of Ne ort RBCs , % ob %& we nteck fo tunsdure ROCs. Trancfusing RBCs whole Blood tranusion » is sorely Ured, only when blood loss is rapid. infusing, Packeel ted Wood cells (PRRCsS whole bloc where arma ord Aus\ouslen Mais is pebertecl foy ceatoriny 0a camying copuedly- ~The _udual blood \oanta Proceolure + - we collect blood trom a donor quel miz it with ut congphart Yaak prover Clottins by binding (ot. Is shelf lide. is 36 days. > Blood is so Woluathe Hur mnoutly ths Seperateel inte tk tomeoneats anol cack tompoueud is woe! when /there ih needled. Human Pood, Grsoups # tranofuiow A incompatible \dloed com too fated > RBCs playa mem Containa marker treat are —glycolipis aul oy coprotein. im which Huyy're calkech hatigen. Antigen: ayttiiing the ody preceiven on foreign al Ant generals an imouune teaponse. ex: dominn, deciles on surte st bac, viewer, cul cancer cella. och yuismetdhecl R&Cs. > Agglutinegens.- “he RECs ontigens Hawk promos _agglutinadion Ly Cotumnjed together clue to mismatch ect A Thore’te other ankiens lout they re used) foc RSLs +rnsfuron. Jegad or atademical chdé ( WS 2 duffy, Kas awk Versis ares) Tyre only neeelel when m person is tngertecl to necck Levene tranafustona in which cws_are Mora Milady to octur. ABO _Blood._ Cares Fanice Voaoeel ow the presence at absence of two agglutinge ns, dap A wel type B . depending su which one the person jwharits Mae rood Ange will lef, B, AB, oO. 7 Te_0 blood gry rave nertner agg lulinagen_, ack sh fre must Common \rtood type in Nora America. PAB howe Looth antigens, is leant Common - > preamue ob gtr Bor B agglubinngn cola in gp her B. Aagglukining 1- is nique ote NRO Nook gree HS a perdormesl antilborlion im Sra Qanmna Thas, act against ABU comming the antigan not preswt on the pertora own RBs. Nevloorn lacs Yuum, bit begin to oppear within A month, cnel reach 9-\6 years. 4.0 blood 4ype . Amcha AB antigen , sl have autift meh anhi-B cutibodien , Hey tre aldo Called 2 ovel b _agglutinina. Pr vlood jype > anti-B B blood Aype > amfi-m AR plocd ype cloesn’t hase autiboolier. Rn_Blood_ Groups Rh doctors: ore ame $4 Rh cpglabtno gens . only % of Hem ace common ( C..%,¢,0\ antigens. Tmonlaey) oth namecl Sine Mis cae originally, He dendified Rn _agilukinogenD im cheown “macagt auk later tel idertthed it ir Iemecons This will Cur Some problem: 4) “the trun fseol plood cella Cont, trunapor* oa 2M Chamrprel PRCA in Simo Bay will Winder Me Vorned Hous te dsuen Nveyond Hinse points. te more dbanisterting is dhe comseynente of huneplorin Anat ercoper into th bloodatream, 7 circudahian heseloin panier Freely nto Ae kidney eJoulen, coming cell cleats, and bicney Shutdown. (EF shutclowin is complete C aeute renal failure) =7 tecigent om die. # Trousftaion Ran mony alse ue. fever, wills, ow BR; rand Near tleenk Nowken._s Vamitian ona renarol tonicity , uk Wwe are etna Lilne Vichnes, Swutdaon. TFeatmend:- fecubes_ow resenting, hic clowneye, oy cuolncnister wid, ave diuretics «ocean! tie “outa Ps utoo rol sai out tw Hh. > Group Disa universal donor, Cur + dest none cmigeun tov B. = Some Aalos one detelapiny a uchhek fo gacymetically clip att Yu. sugar moleades dat specifiy A ov Biolood type . converting tk to Vloodtype 0. A group AB ppl are universeul Yecipi enka» one ty dock anti bocliea fh omt By Hu tay can recelve trom alk \dvock Sypen- Houewer Hebe Clamificodinwa ore miilenclng ONT ty clowt take whe obeount dae ote ogg lutinrgens In blood det con tryger Frampton tn. Audelogous Jromafusions + “the, paticet preclonaler \ir ox \ner ovo Wook» ord vs shored uk immeddiately owailable if nevcleel dung Surgery. [preferred +0 anol Awe isk de Sromwton 12nd tromuission of infecHove ep CHIN) . Picsi Tamm. We odd a Serum Coneinin, ani-h ox onti-® agglutinins to Wood sample dilulech voit Salin_, opilubinatlon vail occur Nockween Hu agglutinin act the correaponeling age lutinogen . : a 's vec g iplents RR. Table 17.4 ABO Blood Groups FREQUENCY (% OF U.S. POPULATION) Anti-B al () Anti-A x PLASMA BLOOD ~ BLOOD RBC ANTIGENS ANTIBODIES THAT CAN NATIVE GROUP (AGGLUTINOGENS) (AGGLUTININS) BE RECEIVED WHITE BLACK ASIAN HISPANIC AMERICAN ABA None A 5 ABABO 4 4 7 2 <1 : 8 “Universal recipient” “8 8 Anti-A (2) g 8,0 119-2510 4 ° Antica A B = “A A Anti-B (b) Anis y AO 4 2 28 3 16 x A 0 None Anti-A (a) O“Universal 45 514057. 79 Anti-B (b) donor” 
