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Creation Date 06-Nov-2010 Revision Date 14-Dec-2020 Revision Number 7
SECTION 1: IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE
COMPANY/UNDERTAKING
1.1. Product identifier Product Description: Acetyl bromide Cat No. : 159400000; 159400050; 159401000; 159405000 Synonyms Ethanoyl bromide CAS-No 506-96- EC-No. 208-061- Molecular Formula C2 H3 Br O Reach Registration Number 01-2119940610- 1.2. Relevant identified uses of the substance or mixture and uses advised against Recommended Use Laboratory chemicals. Uses advised against No Information available 1.3. Details of the supplier of the safety data sheet E-mail address [email protected] 1.4. Emergency telephone number For information US call: 001-800-ACROS-01 / Europe call: +32 14 57 52 11 Emergency Number US:001-201-796-7100 / Europe: +32 14 57 52 99 CHEMTREC Tel. No.US:001-800-424-9300 / Europe:001-703-527-
SECTION 2: HAZARDS IDENTIFICATION
2.1. Classification of the substance or mixture Company UK entity/business name Fisher Scientific UK Bishop Meadow Road, Loughborough, Leicestershire LE11 5RG, United Kingdom EU entity/business name Acros Organics BVBA Janssen Pharmaceuticalaan 3a 2440 Geel, Belgium CLP Classification - Regulation (EC) No 1272/ Health hazards Physical hazards Based on available data, the classification criteria are not met
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Acetyl bromide Revision Date 14-Dec- Full text of Hazard Statements: see section 16 2.2. Label elements Signal Word Danger Hazard Statements H314 - Causes severe skin burns and eye damage EUH014 - Reacts violently with water Combustible liquid Precautionary Statements P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing P310 - Immediately call a POISON CENTER or doctor/physician P280 - Wear protective gloves/protective clothing/eye protection/face protection P301 + P330 + P331 - IF SWALLOWED: Rinse mouth. Do NOT induce vomiting P303 + P361 + P353 - IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water or shower 2.3. Other hazards Water reactive Lachrymator (substance which increases the flow of tears)
SECTION 3: COMPOSITION/INFORMATION ON INGREDIENTS
3.1. Substances Component CAS-No EC-No. Weight % CLP Classification - Regulation (EC) No 1272/ Acetyl bromide 506-96-7 EEC No. 208-061-7 >95 Skin Corr. 1B (H314) Eye Dam. 1 (H318) (EUH014) Reach Registration Number 01-2119940610- Skin Corrosion/Irritation Category 1 B (H314) Serious Eye Damage/Eye Irritation Category 1 (H318) Environmental hazards Based on available data, the classification criteria are not met
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Acetyl bromide Revision Date 14-Dec- As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full protective gear. Thermal decomposition can lead to release of irritating gases and vapors.
SECTION 6: ACCIDENTAL RELEASE MEASURES
6.1. Personal precautions, protective equipment and emergency procedures Use personal protective equipment as required. Evacuate personnel to safe areas. Keep people away from and upwind of spill/leak. Ensure adequate ventilation. Remove all sources of ignition. Take precautionary measures against static discharges. 6.2. Environmental precautions Should not be released into the environment. See Section 12 for additional Ecological Information. 6.3. Methods and material for containment and cleaning up Keep in suitable, closed containers for disposal. Soak up with inert absorbent material. Do not expose spill to water. Remove all sources of ignition. 6.4. Reference to other sections Refer to protective measures listed in Sections 8 and 13.
SECTION 7: HANDLING AND STORAGE
7.1. Precautions for safe handling Do not breathe mist/vapors/spray. Do not get in eyes, on skin, or on clothing. Use only under a chemical fume hood. Wear personal protective equipment/face protection. Do not ingest. If swallowed then seek immediate medical assistance. Do not allow contact with water. Keep away from open flames, hot surfaces and sources of ignition. Hygiene Measures Handle in accordance with good industrial hygiene and safety practice. 7.2. Conditions for safe storage, including any incompatibilities Corrosives area. Keep containers tightly closed in a dry, cool and well-ventilated place. Keep away from water or moist air. Keep away from heat, sparks and flame. Technical Rules for Hazardous Substances (TRGS) 510 Storage Class (LGK) (Germany) Class 8A 7.3. Specific end use(s) Use in laboratories
SECTION 8: EXPOSURE CONTROLS/PERSONAL PROTECTION
8.1. Control parameters Exposure limits This product, as supplied, does not contain any hazardous materials with occupational exposure limits established by the region specific regulatory bodies
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Biological limit values This product, as supplied, does not contain any hazardous materials with biological limits established by the region specific
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Acetyl bromide Revision Date 14-Dec- regulatory bodies Derived No Effect Level (DNEL) / Derived Minimum Effect Level (DMEL) No information available Predicted No Effect Concentration (PNEC) No information available. 8.2. Exposure controls Engineering Measures Ensure adequate ventilation, especially in confined areas. Ensure that eyewash stations and safety showers are close to the workstation location. Wherever possible, engineering control measures such as the isolation or enclosure of the process, the introduction of process or equipment changes to minimise release or contact, and the use of properly designed ventilation systems, should be adopted to control hazardous materials at source Personal protective equipment Eye Protection Goggles (European standard - EN 166) Hand Protection Protective gloves Skin and body protection Long sleeved clothing. Inspect gloves before use. Please observe the instructions regarding permeability and breakthrough time which are provided by the supplier of the gloves. (Refer to manufacturer/supplier for information) Ensure gloves are suitable for the task: Chemical compatability, Dexterity, Operational conditions, User susceptibility, e.g. sensitisation effects, also take into consideration the specific local conditions under which the product is used, such as the danger of cuts, abrasion. Remove gloves with care avoiding skin contamination. Respiratory Protection When workers are facing concentrations above the exposure limit they must use appropriate certified respirators. To protect the wearer, respiratory protective equipment must be the correct fit and be used and maintained properly Large scale/emergency use Use a NIOSH/MSHA or European Standard EN 136 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced Recommended Filter type: Particulates filter conforming to EN 143 Acid gases filter Type E Yellow conforming to EN Small scale/Laboratory use Use a NIOSH/MSHA or European Standard EN 149:2001 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Recommended half mask:- Valve filtering: EN405; or; Half mask: EN140; plus filter, EN 141 When RPE is used a face piece Fit Test should be conducted Glove material Breakthrough time Glove thickness EU standard Glove comments Natural rubber Butyl rubber Nitrile rubber Neoprene PVC See manufacturers recommendations
- EN 374 (minimum requirement)
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Acetyl bromide Revision Date 14-Dec- 10.6. Hazardous decomposition products Carbon monoxide (CO). Carbon dioxide (CO 2 ). Fumes. Hydrogen halides. Thermal decomposition can lead to release of irritating gases and vapors.
SECTION 11: TOXICOLOGICAL INFORMATION
11.1. Information on hazard classes as defined in Regulation (EC) No 1272/ Product Information No acute toxicity information is available for this product (a) acute toxicity; Oral No data available Dermal No data available Inhalation No data available (b) skin corrosion/irritation; Category 1 B (c) serious eye damage/irritation; Category 1 (d) respiratory or skin sensitization; Respiratory No data available Skin No data available (e) germ cell mutagenicity; No data available (f) carcinogenicity; No data available There are no known carcinogenic chemicals in this product (g) reproductive toxicity; No data available (h) STOT-single exposure; No data available (i) STOT-repeated exposure; No data available Target Organs No information available. (j) aspiration hazard; No data available Other Adverse Effects The toxicological properties have not been fully investigated. Symptoms / effects,both acute and delayed Symptoms of overexposure may be headache, dizziness, tiredness, nausea and vomiting. Product is a corrosive material. Use of gastric lavage or emesis is contraindicated. Possible perforation of stomach or esophagus should be investigated. Ingestion causes severe swelling, severe damage to the delicate tissue and danger of perforation. 11.2. Information on other hazards Endocrine Disrupting Properties Assess endocrine disrupting properties for human health. This product does not contain any
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Acetyl bromide Revision Date 14-Dec- known or suspected endocrine disruptors.
SECTION 12: ECOLOGICAL INFORMATION
12.1. Toxicity Ecotoxicity effects Reacts with water so no ecotoxicity data for the substance is available. 12.2. Persistence and degradability No information available Persistence Persistence is unlikely, based on information available. Degradability No information available, Reacts with water. Degradation in sewage treatment plant No information available. Water reactive. 12.3. Bioaccumulative potential Bioaccumulation is unlikely 12.4. Mobility in soil The product contains volatile organic compounds (VOC) which will evaporate easily from all surfaces Will likely be mobile in the environment due to its volatility. Disperses rapidly in air 12.5. Results of PBT and vPvB assessment Water reactive. 12.6. Endocrine disrupting properties Endocrine Disruptor Information This product does not contain any known or suspected endocrine disruptors 12.7. Other adverse effects Persistent Organic Pollutant This product does not contain any known or suspected substance Ozone Depletion Potential This product does not contain any known or suspected substance
SECTION 13: DISPOSAL CONSIDERATIONS
13.1. Waste treatment methods Waste from Residues/Unused Products Waste is classified as hazardous. Dispose of in accordance with the European Directives on waste and hazardous waste. Dispose of in accordance with local regulations. Contaminated Packaging Dispose of this container to hazardous or special waste collection point. European Waste Catalogue (EWC) According to the European Waste Catalog, Waste Codes are not product specific, but application specific. Other Information Waste codes should be assigned by the user based on the application for which the product was used. Do not empty into drains. Do not flush to sewer. Large amounts will affect pH and harm aquatic organisms.
SECTION 14: TRANSPORT INFORMATION
IMDG/IMO
14.1. UN number UN
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Acetyl bromide Revision Date 14-Dec- Full text of H-Statements referred to under sections 2 and 3 H314 - Causes severe skin burns and eye damage H318 - Causes serious eye damage EUH014 - Reacts violently with water Legend Key literature references and sources for data https://echa.europa.eu/information-on-chemicals Suppliers safety data sheet, Chemadvisor - LOLI, Merck index, RTECS Training Advice Chemical hazard awareness training, incorporating labelling, Safety Data Sheets (SDS), Personal Protective Equipment (PPE) and hygiene. Use of personal protective equipment, covering appropriate selection, compatibility, breakthrough thresholds, care, maintenance, fit and standards. First aid for chemical exposure, including the use of eye wash and safety showers. Creation Date 06-Nov- Revision Date 14-Dec- Revision Summary Not applicable.
This safety data sheet complies with the requirements of Regulation (EC) No. 1907/
COMMISSION REGULATION (EU) 2020/878 amending Annex II to Regulation (EC) No
Disclaimer The information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guidance for safe handling, use, processing, storage, transportation, disposal and release and is not to be considered a warranty or quality specification. The information relates only to the specific material designated and may not be valid for such material used in combination with any other materials or in any process, unless specified in the text End of Safety Data Sheet CAS - Chemical Abstracts Service TSCA - United States Toxic Substances Control Act Section 8(b) Inventory EINECS/ELINCS - European Inventory of Existing Commercial Chemical Substances/EU List of Notified Chemical Substances DSL/NDSL - Canadian Domestic Substances List/Non-Domestic Substances List PICCS - Philippines Inventory of Chemicals and Chemical Substances ENCS - Japanese Existing and New Chemical Substances IECSC - Chinese Inventory of Existing Chemical Substances AICS - Australian Inventory of Chemical Substances KECL - Korean Existing and Evaluated Chemical Substances NZIoC - New Zealand Inventory of Chemicals WEL - Workplace Exposure Limit TWA - Time Weighted Average ACGIH - American Conference of Governmental Industrial Hygienists IARC - International Agency for Research on Cancer DNEL - Derived No Effect Level Predicted No Effect Concentration (PNEC) RPE - Respiratory Protective Equipment LD50 - Lethal Dose 50% LC50 - Lethal Concentration 50% EC50 - Effective Concentration 50% NOEC - No Observed Effect Concentration POW - Partition coefficient Octanol:Water PBT - Persistent, Bioaccumulative, Toxic vPvB - very Persistent, very Bioaccumulative ADR - European Agreement Concerning the International Carriage of Dangerous Goods by Road ICAO/IATA - International Civil Aviation Organization/International Air Transport Association IMO/IMDG - International Maritime Organization/International Maritime Dangerous Goods Code MARPOL - International Convention for the Prevention of Pollution from Ships OECD - Organisation for Economic Co-operation and Development ATE - Acute Toxicity Estimate BCF - Bioconcentration factor
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VOC - (Volatile Organic Compound)
