High-Throughput Screening: Discovering New Drugs with Creative Biostructure, Slides of Biology

Download High-Throughput Screening: Discovering New Drugs with Creative Biostructure and more Slides Biology in PDF only on Docsity!

high throughput screening

High-throughput Screening (HTS)

The process of looking for a new drug against a specific target for a certain disease commonly involves

high-throughput screening (HTS), wherein large libraries of chemicals are tested for their ability to

modulate the biological activity of the target. For instance, if the target is a novel GPCR, compounds will

be screened for their ability to inhibit or stimulate the receptor; if the target is a protein kinase, the

chemicals will be tested for their ability to inhibit the kinase. Creative Biostructure provides custom

high-throughput screening services, and our biochemical/cell-based HTS technologies allow us to

efficiently screen hits from a variety of compound libraries.

HTS is a technology system that combines a variety of technical approaches, usually involving robotics,

liquid handling devices, detectors, and specialized software for instrument control and data processing.

It is based on molecular and/or cell-based experimental methods and is performed in the form of

microplates as experimental tools. An automatic operating system is needed to execute the

experimental procedure. During the experiment, the data is collected by fast and sensitive detectors

and then processed and analyzed by specialized software.

Advantages of our High-throughput Screening services:

• We can perform a wide range of HTS approaches and multiple compound library screening.
• We have strict quality control (QC) criteria to control the effectiveness of the HTS process.
• Our team has extensive experience in running automation platforms and large-scale assays.
• We can develop, optimize, and validate HTS approaches according to specific targets or

other research requirements.

• Our achievements in the development and automation of high-throughput crystallography

methods allow us to efficiently screen many small molecules for their ability to bind to

targets, thereby accelerating the process of finding innovative drug candidates.

Creative Biostructure is a reliable partner in drug discovery. For each HTS program, we

recommend suitable screening strategy and protocol according to the specific research

needs of customers and then conduct screening experiments and data collection required

for the project.

Thank you!

Excerpt from:

https://drug-discovery.creative-

biostructure.com/high-throughput-screening-

hts-p