Translation - Human Resource - Lecture Slides, Slides of Human Resource Management

In these Lecture Slides of HRM, the lecturer has illustrated the following major aspects of Human Resource Management : Translation, Certain, Viral, Phosphodiester, Ribosomes, Nucleotide, Transport, Pathways, Dependent, Mechanism

Typology: Slides

2012/2013

Uploaded on 07/26/2013

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Transla'on

retroviruses

Poliovirus

Sindbis virus

Influenza virus

VSV

reovirus

hepaKKs B virus

5’-­‐untranslated region

3 – >1,000 nt in length, typically 50 – 70 nt

Oaen contains RNA secondary structures;

must be unwound to allow passage of

ribosome

Length and secondary structure influence

translaKon efficiency

3’-­‐untranslated region

Can regulate translaKon

iniKaKon, translaKon

efficiency, mRNA stability

poly(A) tail , necessary for

efficient translaKon

TranslaKonal machinery: Ribosomes

RNA=pink, yellow

Protein=blue

Transla'onal machinery

  • Ribosomes
  • tRNAs
  • iniKaKon proteins (eIF)
  • elongaKon proteins (eEF)
  • terminaKon proteins (eRF)

Two mechanisms of ini'a'on

5’-­‐dependent iniKaKon (most mRNAs): iniKaKon

complex binds to 5’-­‐cap structure, and scans in a 3’-­‐

direcKon to the iniKaKon codon

Internal ribosome entry: iniKaKon complex binds at,

or just upstream of, the iniKaKon codon