Interação fármaco-receptor parte 2 | Notas de aula Farmacologia

     





 

        

      





        





        

    





         





     

      

       



          



 

       



 

       



 

 

 

 

 

 

 

       

       



 



          

           

         

           



        

        



          



             

         



            

          



        

       

         



Pré-visualização parcial do texto

Baixe Interação fármaco-receptor parte 2 e outras Notas de aula em PDF para Farmacologia, somente na Docsity!

)$ 50 $& 2 / 2 *,$ $ 8 /$ )$ 50 $& 2 ', 1 Æ 0 ,&$

, 17 ( 5 $d 2 )È 50 $& 2 5 (&( 3725

$)È 50 $& 26 $* 21 , 67 $ 6 ($ 17 $* 21 , 67 $ 6

Ɣ DJRQLVWDV

ż VmR IiUPDFRV TXH VH OLJDP D UHFHSWRUHV DRV UHFHSWRUHV ILVLROyJLFRV H VLPXODP RV HIHLWRV UHJXODGRUHV GRV FRPSRVWRVVLQDOL]DGRUHVHQGyJHQRV Ɣ DJRQLVWDSULPiULR ż VH R IiUPDFR OLJDUVH DR PHVPR VtWLR GH UHFRQKHFLPHQWRGROLJDQWHHQGyJHQR Ɣ DJRQLVWDSDUFLDO ż IiUPDFRV TXH PRVWUDP DSHQDV HILFiFLD SDUFLDO GH XP OLJDQGR UHJXODGRU LQGHSHQGHQWH GD FRQFHQWUDomR XWLOL]DGD Ɣ DJRQLVWDDORVWpULFR ż IiUPDFRV TXH VH OLJDP D XPD UHJLmR GLIHUHQWH GR UHFHSWRUTXHpUHFRQKHFLGDFRPRVtWLRDORVWpULFR Ɣ DJRQLVWDLQYHUVR ż PXLWRV UHFHSWRUHV DSUHVHQWDP DOJXPD DWLYLGDGH FRQVWLWXWLYD GH XP OLJDQGR UHJXODGRU IiUPDFRV TXH HVWDELOL]DP R UHFHSWRU HP XPD FRQIRUPDomR LQDWLYD VmR FRQKHFLGRVFRPRDJRQLVWDVLQYHUVRV 1 D SUHVHQoD GH XP DJRQLVWD SOHQR RV DJRQLVWDV SDUFLDLV H LQYHUVRV FRPSRUWDPVHFRPRDQWDJRQLVWDVFRPSHWLWLYRV Ɣ DQWDJRQLVWDV ż IiUPDFRV TXH EORTXHLDP RX UHGX]HP DomR GH DJRQLVWDV Ɣ DJRQLVWDFRPSHWLWLYR ż IiUPDFRV TXH FRPSHWHP FRP DJRQLVWDV RX OLJDQWHV HQGyJHQRVSHORPHVPRVtWLRGHOLJDomRGRUHFHSWRU Ɣ DJRQLVWDQmRFRPSHWLWLYR Ɣ DJRQLVWDDORVWpULFR ż IiUPDFRVTXHLQWHUDJHPFRPRXWURVtWLRGRUHFHSWRU Ɣ DQWDJRQLVWDTXtPLFR ż IiUPDFRVTXHLQWHUDJHPSRUFRPELQDomRFRPDJRQLVWD ż DXVrQFLDGHLQWHUDomRFRPUHFHSWRU Ɣ DQWDJRQLVWDILVLROyJLFR IXQFLRQDO  ż IiUPDFRV TXH UHDOL]D LQLELomR LQGLUHWD GRV HIHLWRV FHOXODUHV H ILVLROyJLFRV GR DJRQLVWD RX GR OLJDQWH HQGyJHQR ż DXVrQFLDGHLQWHUDomRFRPUHFHSWRU % 5 ( 8 /$d 2 '$$ 7 , 9 ,'$'(' 2 5 (&( 3725* 1 R PRGHOR GR JUiILFR DEDL[R R UHFHSWRU 5 SRGH H[LVWLU HP FRQIRUPDo}HV DWLYD (^5) D RX LQDWLYD (^5) L )iUPDFRV TXH VH OLJDP D XPD GHVVDV FRQIRUPDo}HV GH UHFHSWRU RX D DPEDV SRGHP DIHWDU R HTXLOtEULR HQWUH DV GXDV FRQIRUPDo}HV GH 5 H R HIHLWR ILQDO GDV UHDo}HVFRQWURODGDVSRUHVWHUHFHSWRU 1 D RUGHQDGD HVWi UHSUHVHQWDGD D DWLYLGDGH GR UHFHSWRU SURGX]LGD SHOD FRQIRUPDomR DWLYD 3 RU H[HPSOR D HVWLPXODomR GD DGHQLOLOFLFODVH SRUXPUHFHSWRUEHWDDGUHQpUJLFRDWLYDGR Ɣ VH XP IiUPDFR / OLJDUVH VHOHWLYDPHQWH DR (^5) D Ki SURGXomR GH UHVSRVWDPi[LPD Ɣ VH / WLYHU D PHVPD DILQLGDGH SRU (^5) L H (^5) D QmR Ki JHUDomR GH DOWHUDomR QR HTXLOtEULR HQWUH DV GXDV FRQIRUPDo}HV H QmR Ki SURGXomRGHQHQKXPHIHLWRQDDWLYLGDGHILQDO Ɣ VH / SXGHU OLJDUVH D (^5) D PDV WDPEpP OLJDUVH D (^5) L FRP PHQRV DWLYLGDGH Ki SURGXomR GH XPD UHVSRVWD SDUFLDO H / VHUi XP DJRQLVWDSDUFLDO Ɣ VH KRXYHU (^5) D HP TXDQWLGDGHV VXILFLHQWHV SDUD SURGX]LU XPD UHVSRVWD EDVDO DXPHQWDGD QD DXVrQFLD GR OLJDQGR DWLYLGDGH FRQVWLWXWLYD LQGHSHQGHQWH GR DJRQLVWD H VH / OLJDUVH D (^5) L Ki LQLELomRGDDWLYLGDGHILQDO

ż QHVWHFDVRRIiUPDFR/XPDJRQLVWDLQYHUVR ż DJRQLVWDV LQYHUVRV OLJDPVH VHOHWLYDPHQWH D IRUPD LQDWLYD GR UHFHSWRU H GHVYLDP R HTXLOtEULR FRQIRUPDFLRQDOQRVHQWLGRGRHVWDGRLQDWLYR ż RV UHFHSWRUHV TXH SRVVXHP DWLYLGDGHV FRQVWLWXWLYDV H VmR VHQVtYHLV DR DJRQLVWD LQYHUVR LQFOXHP UHFHSWRUHV SDUD EHQ]RGLD]HStQLFRV UHFHSWRUHV SDUD KLVWDPLQD UHFHSWRUHV RSLyLGHV UHFHSWRUHV FDQDELQyLGHV UHFHSWRUHV SDUD GRSDPLQD EUDGLFLQLQD H DGHQRVLQD SRU H[HPSOR &)È 50 $& 26 $ 21 , 67 $ 6* $ ILJXUD DEDL[R PRVWUD HVTXHPDWLFDPHQWH D UHODomR HQWUH RFXSDomR GRV UHFHSWRUHV IH FRQFHQWUDomR SDUD GRLV IiUPDFRV TXH WrP D PHVPD DILQLGDGH SHOR UHFHSWRU SURGX]LQGR GD RFXSDomR QD

FRQFHQWUDomR GH ȝPRO/ 2 IiUPDFR $ p GHQRPLQDGR DJRQLVWD WRWDO

SURGX]LQGRUHVSRVWDPi[LPDFRP ȝPRO/

$ UHODomR HQWUH UHVSRVWD H RFXSDomR p PRVWUDGD QD FXUYD % &RPSDUDQGRVH FRP R DJRQLVWD SDUFLDO IiUPDFR % HVWH DSUHVHQWD FXUYD EDL[D QR JUiILFR $ H QR JUiILFR % VHQGR D GLIHUHQoD HQWUH D UHVSRVWD H D RFXSDomR PXLWR SHTXHQD SDUD XP DJRQLVWD SDUFLDO R TXDO QmR SURGX] UHVSRVWD Pi[LPD PHVPR FRP GH RFXSDomR GRV UHFHSWRUHV ,VVR p H[SUHVVR TXDQWLWDWLYDPHQWH SHOD HILFiFLD XP SDUkPHWUR TXH GHVFUHYH D IRUoD GR FRPSOH[R DJRQLVWDUHFHSWRU HP SURGX]LUUHVSRVWDQRWHFLGR $VVLP IiUPDFRV FRP HILFiFLD SURGX]HP UHVSRVWD Pi[LPD DJRQLVWDV WRWDLV HQTXDQWR IiUPDFRV FRP HILFiFLD PHQRU GR TXH SURGX]HP UHVSRVWDV VXEPi[LPDV 3 RU RXWUR ODGR IiUPDFRV FRP HILFiFLD QmR FDXVDP DWLYDomR GR UHFHSWRU H QmR LQGX]HP XPD UHVSRVWDQRWHFLGRVHQGRDQWDJRQLVWDV 4 XDQGR D SRWrQFLD UHODWLYD GH GRLV DJRQLVWDV FRP D PHVPD HILFiFLD p PHGLGD QR PHVPR VLVWHPD ELROyJLFR H DV UHVSRVWDV VLQDOL]DGRUDV VXEVHTXHQWHV VmR LJXDLV FRP GRLV IiUPDFRV VXD FRPSDUDomR IRUQHFH XPDPHGLGDUHODWLYDGDDILQLGDGHHGDHILFiFLDGRV GRLVDJRQLVWDV Ɣ QRUPDOPHQWH GHVFUHYHVH DV UHVSRVWDV DJRQLVWDV GHWHUPLQDQGRVH D PHLD FRQFHQWUDomR HILFD] &( SDUD SURGX]LUGHWHUPLQDGRHIHLWR Ɣ WDPEpP SRGHVH FRPSDUDU DV DVVtQWRWDV Pi[LPDV GRV VLVWHPDV TXDQGR RV DJRQLVWDV QmR SURGX]HP UHVSRVWDV Pi[LPDV

$FLPD WHPVH D FXUYD GH FRQFHQWUDomR UHIHUHQWH D IDPtOLD GR PHW{QLR VXEVWLWXtGR VRE R P~VFXOR UHWRDEGRPLQDO GH Um 2 GHFDPHW{QLR HVWUXWXUD TXtPLFD DSUHVHQWDGD TXDQGR VRIUH DOWHUDomR QRV VHXV UDGLFDLV SURGX] VXEVWkQFLDV FDSD]HV GH LQWHUDJLU GH IRUPD GLVWLQWD FRP RV UHFHSWRUHV H SRU LVVR DV UHVSRVWDV REVHUYDGDV WDPEpP VmR GLVWLQWDV 'H IRUPD JHUDO REVHUYDVH TXH Ki UHGXomR GD UHVSRVWD Pi[LPD FRP DXPHQWR GR YROXPH GH VXEVWLWXLomR 5 6 H 5 IRU XP PHWLO D UHVSRVWD Pi[LPD HVWi HP WRUQR GH GH PRGR TXH R IiUPDFR p XP DJRQLVWD SDUFLDO 6 H 5 IRU XP HWLO p QHFHVViULR D XWLOL]DomR GH XPD PDLRU FRQFHQWUDomR GR IiUPDFR SDUD TXH VHMD REVHUYDGR R HIHLWR Pi[LPR GH 6 H 5 IRU QSURSLO p QHFHVViULR D XWLOL]DomR GH XPD FRQFHQWUDomR GH IiUPDFR PDLRU DLQGD SDUD TXH VH REVHUYH XP HIHLWR Pi[LPR GH 4 XDQGR R VXEVWLWXLQWH p PXLWR YROXPRVR R IiUPDFR RFXSD R UHFHSWRU PDV QmR p FDSD] GH DWLYDOR GH PRGR TXH SDVVD D VHU XP DQWDJRQLVWD 6 HQGR DVVLP R GHFDPHW{QLR p XP DQWDJRQLVWD (VWH IiUPDFRpXWLOL]DGRFRPRXPEORTXHDGRUQHXURPXVFXODU  DJRQLVWDVRXFRDJRQLVWDVDORVWpULFRV 8 P IiUPDFR SRGH VH OLJDU D XP ORFDO GR UHFHSWRU GLIHUHQWH GDTXHOH RFXSDGR SHOR DJRQLVWD SULPiULD DOWHUDQGR D DILQLGDGH GR UHFHSWRU SHOR DJRQLVWD 1 HVWH FDVR SRGH KDYHU SRWHQFLDOL]DomR GRV HIHLWRV GRV DJRQLVWDV SULPiULRV (VWH IiUPDFR SRGH VHU GHVFULWR FRPR DJRQLVWD RX FRDJQRVWLFDDORVWpULFR 2 V EHQ]RGLD]HStQLFRV VmR FRQVLGHUDGRV PRGXODGRUHV DORVWpULFRV SRVLWLYRV SRLV VH ORJDP FRPSHWLWLYDPHQWH D FDQDLV L{QLFRV DWLYDGRV SHOR QHXURWUDQVPLVVRU iFLGR JDPDDPLQREXWtULFR *$%$ DXPHQWDQGR R HIHLWR OtTXLGR DWLYDGRU GR *$%$ VREUH D FRQGXWkQFLD GH FDQDLV GH FORUHWR

')È 50 $& 26 $ 17 $* 21 , 67 $ 6

2 V DQWDJRQLVWDV GLYLGHPVH DQWDJRQLVWDV GH UHFHSWRUHV H

DQWDJRQLVWDVVHPUHFHSWRUHVFRPRREVHUYDGRQDHVWUXWXUD DEDL[R

'HQWUH RV DQWDJRQLVWDV GH UHFHSWRUHV WHPVH RV GH OLJDomR DR VtWLR DWLYR TXH SRGH VHU FODVVLILFDGD FRPR UHYHUVtYHO RX LUUHYHUVtYHO H RV GH OLJDomR DORVWpULFD (P UHODomR DRV DQWDJRQLVWDV GH OLJDomR DR VtWLR UHYHUVtYHO WHPVH RV DQWDJRQLVWDV FRPSHWLWLYRV (VWH p R FDVR GR SURSDQRORO XP DQWDJRQLVWD FRPSHWLWLYR GD QRUDGUHQDOLQD (P UHODomR DRV DQWDJRQLVWDV GH OLJDomR DR VtWLR LUUHYHUVtYHO WHPVH RV DQWDJRQLVWDV QmR FRPSHWLWLYRV (VWH p R FDVR GD IHQR[LEHQ]DPLQD TXH p XP DQWDJRQLVWD LUUHYHUVtYHO GD QRUDGUHQDOLQD $ OLJDomR DORVWpULFDWDPEpPSRGHVHUUHYHUVtYHORXLUUHYHUVtYHO 1 D FODVVLILFDomR GRV DQWDJRQLVWDV VHP UHFHSWRUHV WHPVH R DQWDJRQLVPR TXtPLFR H R DQWDJRQLVPR ILVLROyJLFR 8 P H[HPSOR GH DQWDJRQLVPRTXtPLFRpDLQWHUDomRGD SURWDPLQD FRP DKHSDULQD 2 V SDGU}HV WtSLFRV GH DQWDJRQLVWDV HVWmR DVVRFLDGRV D FHUWRV PHFDQLVPRVGHEORTXHLRVGHUHFHSWRUHV  DQWDJRQLVWDVFRPSHWLWLYRV 1 RV DQWDJRQLVWDV FRPSHWLWLYRV XP IiUPDFR FRP DILQLGDGH SRU VHX UHFHSWRU PDV VHP HILFiFLD LQWUtQVHFD FRPSHWH FRP DJRQLVWD SHOR ORFDO GH OLJDomR SULPiULR GR UHFHSWRU 2 SDGUmR GHVWH DQWDJRQLVPR p D SURGXomR FRQFHQWUDomRGHSHQGHQWH GH XP GHVYLR SURSRUFLRQDO D GLUHLWD GD FXUYD GRVHGHSHQGHQWH GR DJRQLVWD VHP TXDOTXHU DOWHUDomR QD UHVSRVWD Pi[LPD LVWR p DXPHQWDU D FRQFHQWUDomR QHFHVViULD GR OLJDQWH GR UHFHSWRU SDUD SURGXomR GR PHVPR HIHLWR Pi[LPR $ PDJQLWXGH GR GHVYLR GD FXUYD D GLUHLWD GHSHQGH GD FRQFHQWUDomR GR DQWDJRQLVWDHGDVXDDILQLGDGHSHORUHFHSWRU 3 RU H[HPSOR R SURSDQRORO HP GRVHV VXILFLHQWHV SDUD EORTXHDU R QtYHO EDVDO GH QRUDGUHQDOLQD UHGX] D IUHTXrQFLD FDUGtDFD HP UHSRXVR 0 DV XP DXPHQWR QD OLEHUDomR GH QRUDGUHQDOLQD FDXVDGD SRU H[HUFtFLRV PXGDQoD SRVWXUDO RX HVWUHVVH HPRFLRQDO SRGH VHU VXILFLHQWH SDUD VXSHUDU R DQWDJRQLVPR FRPSHWLWLYR H[HUFLGR SHOR SURSDQRORO GH PRGR TXH D IUHTXrQFLD FDUGtDFD DXPHQWD LQIOXHQFLDQGR QD UHVSRVWD WHUDSrXWLFD 1 D SUHVHQoD GH XP DQWDJRQLVWD FRPSHWLWLYR D FXUYD GH FRQFHQWUDomR GR DJRQLVWD p GHVYLDGD SDUD D GLUHLWD VHP RFRUUHU DOWHUDomR QD LQFOLQDomR RX QR YDORU Pi[LPR H R JUDXGHVWHGHVYLRFRUUHVSRQGHDPHGLGDGDUD]mRGD GRVH  DQWDJRQLVWDVQmRFRPSHWLWLYRVLUUHYHUVtYHLV 8 P IiUPDFR SRGH GLVVRFLDUVH WmR OHQWDPHQWH GH XP UHFHSWRU TXH VXD DomR p H[FHVVLYDPHQWH ORQJD (P SUHVHQoD GH XP DQWDJRQLVWD FRP GLVVRFLDomR OHQWD D UHVSRVWD Pi[LPD GR DJRQLVWD p GHSULPLGD HP DOJXPDV FRQFHQWUDo}HV GR DQWDJRQLVWD 1 D SUiWLFD LVVR p GHVFULWR FRPR DQWDJRQLVPR QmR FRPSHWLWLYR HPERUD R PHFDQLVPR GH DomR PROHFXODUQmRSRVVDVHULQIHULGR 2 DQWDJRQLVWD LUUHYHUVtYHO SURGX] XP SDGUmR GH DQWDJRQLVPR FRPR REVHUYDGR QR JUiILFR DEDL[R $ IHQR[LEHQ]DPLQD p XP DQWDJRQLVWD GH UHFHSWRU DOIDDGUHQpUJLFR XVDGR SDUD FRQWURODU D KLSHUWHQVmR DUWHULDO FDXVDGD SRU FDWHFRODPLQDV OLEHUDGDV SHOR IHRFURPRFLWRPD XP WXPRU EHQLJQR GD PHGXOD GD VXSUDUUHQDO H FRPSRVWR SRU FpOXODV FURPDILQV

$ OLJDomR GH XP DJRQLVWD DR VHX UHFHSWRU LQGX] DOWHUDo}HV FRQIRUPDFLRQDLV QRV UHFHSWRUHV R SULPHLUR SDVVR SDUD LQGXomR GH XPD UHVSRVWD IDUPDFROyJLFD $ HILFLrQFLD GR DFRSODPHQWR TXH FRQVLVWH QD RFXSDomR GR UHFHSWRU SHOR IiUPDFR H QD UHVSRVWD IDUPDFROyJLFD p GHWHUPLQDGD QR UHFHSWRU $SyV R DFRSODPHQWR HYHQWRV ELRTXtPLFRV WUDQVIRUPDP D RFXSDomR GR UHFHSWRU HP UHVSRVWD 8 P GRV IDWRUHV TXH FRQWULEXHP SDUD R DFRSODPHQWR RFXSDomR GR UHFHSWR QmR OLQHDU p R GH UHFHSWRU UHVHUYD RX UHFHSWRUVREUHVVDOHQWH 5 HFHSWRUHV VmR UHVHUYDV SDUD XPD GHWHUPLQDGD UHVSRVWD IDUPDFROyJLFD VH IRU SRVVtYHO SURYRFDU XPD UHVSRVWD ELROyJLFD Pi[LPD HP XPD FRQFHQWUDomR GH DJRQLVWD TXH QmR UHVXOWH QD RFXSDomR GR Q~PHUR FRPSOHWR GH UHFHSWRUHV GLVSRQtYHLV $VVLP RV UHFHSWRUHV UHVHUYDV VmR GHPRQVWUDGRV H[SHULPHQWDOPHQWH SHOR XVR GH DQWDJRQLVWDV LUUHYHUVtYHLV R TXH SRGH VHU REVHUYDGR QR JUiILFR DEDL[R $ FXUYD $ PRVWUD D UHVSRVWD GR DJRQLVWD QD DXVrQFLD GH XP DQWDJRQLVWD 'HSRLV GR WUDWDPHQWR FRP XPD FRQFHQWUDomR EDL[D GR DQWDJRQLVWD FXUYD % D FXUYD $ p GHVYLDGD SDUD D GLUHLWD &RQWXGR D FDSDFLGDGH GH UHVSRVWD Pi[LPD p SUHVHUYDGD SRUTXH RV UHFHSWRUHV GLVSRQtYHLV UHPDQHVFHQWHV DLQGD H[FHGHP R Q~PHUR QHFHVViULR SDUD D UHVSRVWD 1 D FXUYD & SURGX]LGD GHSRLV GR WUDWDPHQWR GD FXUYD $ FRP XPD FRQFHQWUDomR PDLRU GR DQWDJRQLVWD RV UHFHSWRUHV GLVSRQtYHLV QmR HVWmR PDLV GH UHVHUYD VHQGR DSHQDV VXILFLHQWHV SDUD PHGLDU XPD UHVSRVWD Pi[LPD QmR GLPLQXtGD &RQFHQWUDo}HV DLQGD PDLV DOWDV GR DQWDJRQLVWD REVHUYDGDV QDV FXUYDV ' H ( UHGX]HP R Q~PHUR GH UHFHSWRUHV GLVSRQtYHLV DR SRQWR HP TXH D UHVSRVWD Pi[LPDpGLPLQXtGD $ (& DSDUHQWH GR DJRQLVWD QDV FXUYDV ' H ( SRGH VH DSUR[LPDU GH .' TXH FDUDFWHUL]D D DILQLGDGH GH OLJDomR GR DJRQLVWD SHOR UHFHSWRU ,VVR SRGH DFRQWHFHU FRP UHFHSWRUHV EHWDDGUHQpUJLFRV SRU H[HPSOR TXHHVWmRHPJUDQGHSURSRUomRQDVFpOXODVGRPLRFiUGLR 8 PD UHVSRVWD Pi[LPD GR P~VFXOR FDUGtDFR D FDWHFRODPLQDV SRGH VHU SURYRFDGD DLQGD TXDQGR GRV UHFHSWRUHV HVWLYHUHP RFXSDGRV SRU DQWDJRQLVWDVTXDVHLUUHYHUVtYHLV (P DOJXQV FDVRV RV UHFHSWRUHV UHVHUYDV VLPSOHVPHQWH VREUDP HP Q~PHUR HP UHODomR DR Q~PHUR WRWDO GH PHGLDGRUHV GH VLQDOL]DomR SUHVHQWHV QDV FpOXODV GH PRGR TXH D UHVSRVWD Pi[LPD SRGH RFRUUHU VHP D RFXSDomR GH WRGRV RV UHFHSWRUHV 3 RU H[HPSOR D DWLYDomR GH XP UHFHSWRU EHWDDGUHQpUJLFR SRU XP DJRQLVWD DWLYD XPD FDVFDWD GH VLQDOL]DomR TXH SRGH VHU DPSOLILFDGD H D UHVSRVWD Pi[LPD p REVHUYDGD SRU DWLYDomR GH SRXFRV UHFHSWRUHV 3 RU LVVR D VHQVLELOLGDGH GH XPD FpOXOD RX XP WHFLGR D XPD FRQFHQWUDomR GH DJRQLVWD GHSHQGH WDQWR GD VXD DILQLGDGH SHOR UHFHSWRU .' TXDQWR GR JUDX GH VREUD GH UHFHSWRUHV FRPSDUDGR FRP R Q~PHUR WRWDOQHFHVViULRSDUDSURYRFDUXPDUHVSRVWDPi[LPD

)'( 66 ( 16 ,%,/,=$d 2 7 $ 48 ,),/$;,$ $V UHVSRVWDV PHGLDGDV SRU UHFHSWRUHV FRPR SRU H[HPSOR *UHFHSWRUHV DFRSODGRV D SURWHtQDV V GH IiUPDFRV RX DOJXQV DJRQLVWDV KRUPRQDLV QRUPDOPHQWH VH DWHQXDP FRP R WHPSR $SyV DOFDQoDU XP DOWR QtYHO LQLFLDO D UHVSRVWD Pi[LPD GLPLQXL DR ORQJR GH VHJXQGRV RX PLQXWRV PHVPR QD SUHVHQoD FRQWLQXDGD GH DJRQLVWDV (VVD GHVVHQVLELOL]DomR RX WDTXLILOD[LD FRVWXPD VHU UDSLGDPHQWH UHYHUVtYHO GH PRGR TXH XPD VHJXQGD H[SRVLomR DR DJRQLVWD VH UHDOL]DGD HP SRXFRV PLQXWRV GHSRLV GR WpUPLQR GD SULPHLUD H[SRVLomRUHVXOWDHPXPDUHVSRVWDVHPHOKDQWHDLQLFLDO 0 XLWRV UHFHSWRUHV DFRSODGRV D SURWHtQDV *V VmR UHJXODGRV SRU IRVIRULODomR FRPR LOXVWUDGR SHOD GHVVHQVLELOL]DomR UiSLGD GRV UHFHSWRUHV EHWDDGUHQpUJLFRV $ DOWHUDomR GD FRQIRUPDomR GR UHFHSWRU LQGX]LGD SHOR DJRQLVWD ID] FRP TXH HOH VH OLJXH DWLYH H VLUYD FRPR VXEVWUDWR SDUD XPD IDPtOLD GH FLQDVHV UHFHSWRUDV HVSHFtILFDV GHQRPLQDGDV FLQDVHV UHFHSWRUDV DFRSODGDV D SURWHtQD * * 5 .V SUHVHQWHVQRVSURFHVVRVHGDILJXUDDFLPD $ * 5. DWLYDGD IRVIRULOD UHVtGXRV GH VHULQD QD FDXGD WHUPLQDO FDUER[LOD GR UHFHSWRU $ SUHVHQoD GH IRVIRVVHULQDV DXPHQWD D DWLYLGDGH GR UHFHSWRU SDUD VH OLJDU D EHWDDUUHVWLQD ȕ$UU R TXH GLPLQXL D FDSDFLGDGH GH R UHFHSWRU LQWHUDJLU FRP D SURWHtQD * UHGX]LQGR D UHVSRVWD DR DJRQLVWD &RP D UHPRomR GR DJRQLVWD WHUPLQDVH D DWLYDomR GH * 5. H R SURFHVVR GH GHVVHQVLELOL]DomR SRGH VHU UHYHUWLGR SRU IRVIDWDVHVFHOXODUHV 3 DUD UHFHSWRUHV EHWDDGUHQpUJLFRV H PXLWRV RXWURV UHFHSWRUHV DFRSODGRV D SURWHtQDV *V D OLJDomR FRP D EHWDDUUHVWLQD WDPEpP DFHOHUD D HQGRFLWRVH GH UHFHSWRUHV SURFHVVR D SDUWLU GD PHPEUDQD SODVPiWLFD $ HQGRFLWRVH GH UHFHSWRUHV SURPRYH VXD GHVIRVIRULODomR SRU XPD IRVIDWDVH SURFHVVR SUHVHQWH HP DOWD FRQFHQWUDomR QDV PHPEUDQDV GRV HQGRVVRPRV GH PRGR TXH RV UHFHSWRUHV UHWRUQDP D PHPEUDQD SODVPiWLFD SURFHVVR ,VVR DMXGD D H[SOLFDU D FDSDFLGDGH GD FpOXOD GH UHFXSHUDU R SRGHU GH UHVSRVWD D VLQDOL]DomR PHGLDGD SRU UHFHSWRUHV GH PDQHLUD PXLWR HILFLHQWH GHSRLV GDVHQVLELOL]DomRLQGX]LGDSRUDJRQLVWD 9 iULRV UHFHSWRUHV DFRSODGRV D SURWHtQDV * LQFOXVLYH UHFHSWRUHV EHWDDGUHQpUJLFRV VRIUHP GHJUDGDomR SHORV OLVRVVRPRV VH DWLYDGRV SHUVLVWHQWHPHQWH SURFHVVR (VVH SURFHVVR DWHQXD GH IRUPD HIHWLYD DR LQYpV GH UHVWDEHOHFHU D FDSDFLGDGH GD UHVSRVWD FHOXODUGHPRGRVLPLODUDRSURFHVVRGHUHJXODomRSDUD EDL[R $VVLP D GHSHQGHU GR UHFHSWRU HP SDUWLFXODU H GD GXUDomR GD DWLYDomR D HQGRFLWRVH SRGH UHJXODU FRP IOH[LELOLGDGH RV HIHLWRV GRV IiUPDFRV RX DJRQLVWDVHQGyJHQRV

ż S H[ LQLELGRUHV GH (&$ XWLOL]DGRV SDUD R WUDWDPHQWR GD KLSHUWHQVmR DUWHULDO DXWDFyLGHV GHULYDGRV GH OLStGHRV TXH LQLEHP D HQ]LPD & 2 ; H XWLOL]DGRV SDUD WUDWDPHQWRGDLQIODPDomR Ɣ UHFHSWRUHVGHIiUPDFRVDVVRFLDGRVDSURFHVVRVH[WUDFHOXODUHV ż DOJXQV IiUPDFRV WrP FRPR DOYR HQ]LPDV H PROpFXODV TXH FRQWURODP RV SURFHVVRV H[WUDFHOXODUHV FRPR WURPERVHLQIODPDomRHUHDo}HVLPXQHV ż S H[ R VLVWHPD GH FRDJXODomR p FRQWURODGR ULJRURVDPHQWH H WHP DOJXQV DOYRV IDUPDFROyJLFRV TXH FRQWURODP D IRUPDomR H GHFRPSRVLomR GRV WURPERV LQFOXVLYH YiULRV IDWRUHV GH FRDJXODomR FRPR WURPELQD IDWRU;DHJOLFRSURWHtQDVGHVXSHUItFLHVGDVSODTXHWDV Ŷ DOJXQV H[HPSORV GH IiUPDFRV TXH DJHP QHVWH VLVWHPD GDELJDWUDQD LQLELGRU GD WURPELQD KHSDULQD H HQR[DSDULQD DQWLFRDJXODQWHV ULYDUR[DEDQD LQLELGRU GR IDWRU ;D iFLGR DFHWLO VDOLFtOLFR LQLELGRU GD FLFORR[LJHQDVH , FORSLGRJUHO LQLELGRU LUUHYHUVtYHO GR UHFHSWRU 3 < WLFDJUHORU LQLELGRU UHYHUVtYHO GR UHFHSWRU 3 < VmR DQWLSODTXHWiULRV TXH DJHP SRUPHFDQLVPRVGLVWLQWRV Ŷ HSWLILEDWLGH p XP DQWDJRQLVWD GH * 3 ,,E,,,D XPD LQWHUJLQD GH VXSHUItFLH SODTXHWiULD H p XVDGD SDUD LQWHUYHQomR FRURQDULDQD SDUD VtQGURPHFRURQDULDQDDJXGD Ɣ UHFHSWRUHVXVDGRVSRUDJHQWHVLQIHFFLRVRV ż DOJXQV IiUPDFRV DQWLLQIHFFLRVRV FRPR DQWLELyWLFRV DQWLYLUDLV H DQWLSDUDVLWiULRV DOFDQoDP HVSHFLILFLGDGH SRLV DWXDP HP UHFHSWRUHV SURWHtQDV PLFURELDQDV RX HP SURFHVVRV FHOXODUHV HVVHQFLDLV D SUROLIHUDomR H VREUHYLGD GR DJHQWH LQIHFFLRVR PDV QmR VmR HVVHQFLDLVRXQmRH[LVWHPQRRUJDQLVPRWUDWDGR ż D UHVLVWrQFLD D HVWHV IiUPDFRV SRGH VHU FDXVDGD SRU YiULRVPHFDQLVPRVLQFOXVLYH Ŷ PXWDomR GR UHFHSWRU DOYR DPSOLDomR GD H[SUHVVmR GH HQ]LPDV TXH GHFRPS}HP RX DXPHQWDP H[SXOVmR GRV IiUPDFRV SHOR DJHQWH LQIHFFLRVR Ŷ GHVHQYROYLPHQWR GH UHDo}HV ELRTXtPLFDV DOWHUQDWLYDV TXH HYLWDP R HIHLWR GRV IiUPDFRV QR DJHQWHLQIHFFLRVR Ɣ UHFHSWRUHVTXHUHJXODPRHTXLOtEULRL{QLFR ż SRXFRV IiUPDFRV DWXDP QD UHJXODomR GR HTXLOtEULR L{QLFRGRVDQJXHGDXULQDHGR 7 *, ż RV UHFHSWRUHV GHVWHV IiUPDFRV VmR ERPEDV H WUDQVSRUWDGRUHV L{QLFRV GRV TXDLV PXLWRV VmR H[SUHVVRV DSHQDV QDV FpOXODV HVSHFLDOL]DGDV GRV ULQV H GRVLVWHPDJDVWURLQWHVWLQDO ż RV GLXUpWLFRV IXURVHPLGD KLGURFORURWLD]LGD H DPLORULGD DWXDP DOWHUDQGR GLUHWDPHQWH DV ERPEDV H WUDQVSRUWDGRUHV L{QLFRV GDV FpOXODV HSLWHOLDLV GR QpIURQ R TXH FDXVD DXPHQWR GD WUDQVIHUrQFLD GH VyGLR SDUD D XULQDSRUPHFDQLVPRVGLVWLQWRV +& 21 &(, 726 (IHLWR WHUDSrXWLFR VmR RV HIHLWRV EHQpILFRV FDXVDGRV SHOR IiUPDFR QR RUJDQLVPR GH TXHP R FRQVXPLX e LPSRUWDQWH GHVWDFDU TXH R PHVPR IiUPDFR SRGH DSUHVHQWDU HIHLWRV WHUDSrXWLFRV GLIHUHQWHV HP RXWURV LQGLYtGXRV GHYLGR D IDWRUHV FRPR JrQHUR LGDGH SHVR XVR GH iOFRRO RX GH WDEDFR DOpP GH DOJXPDV GRHQoDV FRPR SUREOHPDV KHSiWLFRV SUREOHPDV FDUGtDFRV DQHPLD GHQWUH RXWURV R TXH SRGH LQWHUIHULU QR UHVXOWDGRILQDOGDWHUDSLD (IHLWR FRODWHUDO p XP HIHLWR QmR SUHWHQGLGR DGYHUVR RX EHQpILFR FDXVDGR SRU PHGLFDPHQWR XWLOL]DGR HP GRVHV UHSHWLGDV $ SDODYUD FRODWHUDO GHQRWD DOJR GH LPSRUWkQFLD VHFXQGiULD GH IRUPD TXH R XVR GHVWD H[SUHVVmR SRGH PLQLPL]DU D SHUFHSomR GH GDQR TXDQGR R HIHLWR p SUHMXGLFLDO &RPR HVWH WHUPR p IUHTXHQWHPHQWH XWLOL]DGR GH IRUPD

LQDSURSULDGD D $JrQFLD (XURSHLD GH 0 HGLFDPHQWRV ( 0 $ R FRQVLGHUDXOWUDSDVVDGRHUHFRPHQGDDDEROLomRGDVXD XWLOL]DomR (IHLWR DGYHUVR p R HIHLWR SUHMXGLFLDO RX LQGHVHMDGR TXH RFRUUH GXUDQWH RX DSyV XPD LQWHUYHQomR RX XVR GH PHGLFDPHQWR HP TXH Ki SRVVLELOLGDGH UD]RiYHO GH UHODomR FDXVDO HQWUH R WUDWDPHQWR H R HIHLWR 3 RU H[HPSOR FRP R XVR GH HQDODSULO RX FDSWRSULO PHGLFDPHQWRV DQWLKLSHUWHQVLYRV SRGH VXUJLU XPD WRVVH VHFD H LQWHUPLWHQWH H TXH DSHQDV FHVVD FRP D LQWHUUXSomR GR WUDWDPHQWR FRP R IiUPDFR DSUHVHQWDGR 5 HDomR DGYHUVD DR PHGLFDPHQWR 5 $ 0 p TXDOTXHU UHDomR SUHMXGLFLDO RX LQGHVHMiYHO QmR LQWHQFLRQDO D XP PHGLFDPHQWR TXH RFRUUH QDV GRVHV XVXDOPHQWH HPSUHJDGDV SDUD SURILOD[LD GLDJQyVWLFR WHUDSLD GD GRHQoD RX SDUD PRGLILFDomR GH IXQo}HV ILVLROyJLFDV $ 5 $ 0 p FDUDFWHUL]DGD SHOD H[LVWrQFLD GH XPD UHODomR FDXVDO HVSHFtILFD HQWUH R PHGLFDPHQWR H D RFRUUrQFLD 7 RGD UHDomR DGYHUVD D XP PHGLFDPHQWR p XP HYHQWR DGYHUVR SRUpP QHP WRGR HYHQWR DGYHUVR p XPD 5 $ 0 7 DPEpP p LPSRUWDQWH GHVWDFDU D GLIHUHQoD HQWUH 5 $ 0 H LQWR[LFDomR PHGLFDPHQWRVD $ SULPHLUD RFRUUH FRP R XVR GR PHGLFDPHQWR HP GRVHWHUDSrXWLFDHDVHJXQGDRFRUUHHPVXSHUGRVH (YHQWR DGYHUVR p XP HYHQWR GHVIDYRUiYHO TXH RFRUUH GXUDQWH RX DSyV R XVR GH PHGLFDPHQWR RX RXWUD LQWHUYHQomR 3 DUD VHU FRQVLGHUDGR XP HYHQWR DGYHUVR XP PHGLFDPHQWR RX D LQWHUYHQomR QmR QHFHVVDULDPHQWH WHP UHODomR FDXVDO FRP R HYHQWR SRU H[HPSOR LQIHFo}HV UHODFLRQDGDV D DVVLVWrQFLD D VD~GH , 5 $ 6 IOHELWH IRUPDomR GH FRiJXOR VDQJXtQHR QR LQWHULRU GH XPD YHLD LPSHGLQGR R IOX[R VDQJXtQHR REVWUXomR GH VRQGD SDUD DOLPHQWDomR UHDo}HV DGYHUVDV D PHGLFDPHQWRV HYHQWRV DGYHUVRV SRU GHVYLRV GH TXDOLGDGH GH PHGLFDPHQWRV HYHQWRV DGYHUVRV GHFRUUHQWHV GH XVR QmR DSURYDGR GH PHGLFDPHQWRV XVR RII ODEHO LQWHUDo}HV PHGLFDPHQWRVDV LQHIHWLYLGDGH WHUDSrXWLFD WRWDO RX SDUFLDO HUURV GH PHGLFDomR SRWHQFLDLVHUHDLVHTXHGDGRSDFLHQWH 8 P HYHQWR DGYHUVRV p FRQVLGHUDGR JUDYH TXDQGR SRU H[HPSOR OHYD D yELWR RX D DPHDoD D YLGD TXDQGR JHUD KRVSLWDOL]DomR RX SURORQJDPHQWR GD LQWHUQDomR GD LQWHUQDomR Mi H[LVWHQWH DOpP GH LQFDSDFLGDGHHDQRPDOLDFRQJrQLWD 5 HDo}HV LGLRVVLQFUiWLFDV D PHGLFDPHQWRV QmR VmR PXLWR FRPXQV H RFRUUHP HP XPD SDUFHOD SHTXHQD GD SRSXODomR TXDQGR VH FRPSDUDGDV DRV HIHLWRV DGYHUVRV DSUHVHQWDGRV QR XVR GH PHGLFDPHQWRV GH IRUPD JHUDO (VVDV UHDo}HV WDPEpP VmR QRFLYDV DR RUJDQLVPR KXPDQR SRGHQGR FXOPLQDU QD PRUWH GR SDFLHQWH 1 D PDLRULD GDV YH]HV WUDWDVH GH XPD VHQVLELOLGDGH TXH FHUWRV LQGLYtGXRV DSUHVHQWDP QHVWH FDVR SDUWLFXODU D XP PHGLFDPHQWR PRWLYDGD SRU XPD HVWUXWXUD RX DWLYLGDGH PRGLILFDGD GH XPD SURWHtQD LPSRUWDQWH SDUDDomRRXGHJUDGDomRGRIiUPDFRHPTXHVWmR (VVD PXGDQoD QR HVWDGR FRQIRUPDFLRQDO GDV SURWHtQDV VH GHYH HP JHUDO DR SROLPRUILVPR JHQpWLFR TXH VmR DV GLIHUHQoDV QR ' 1 $ HQWUH XPD SHVVRD H RXWUD H TXH PRGLILFDP FHUWRV JHQHV FXMR SURGXWR ILQDO VmR WDLV SURWHtQDV 3 RU H[HPSOR D DQHPLD KHPROtWLFD SRGH VHU KHUGDGD SRU XPD PXWDomR JHQpWLFD HP DOJXQV LQGLYtGXRV H SRGH RFRUUHU TXDQGR HP XVR GR PHGLFDPHQWR TXLQDFULQD TXH p XWLOL]DGR SDUDWUDWDPHQWRGDPDOiULD

Interação fármaco-receptor parte 2, Notas de aula de Farmacologia

Documentos relacionados

Pré-visualização parcial do texto

Baixe Interação fármaco-receptor parte 2 e outras Notas de aula em PDF para Farmacologia, somente na Docsity!

)$ 50 $& 2 / 2 *,$ $ 8 /$ )$ 50 $& 2 ', 1 Æ 0 ,&$

, 17 ( 5 $d 2 )È 50 $& 2 5 (&( 3725

$)È 50 $& 26 $* 21 , 67 $ 6 ($ 17 $* 21 , 67 $ 6

Ɣ DJRQLVWDV

FRQFHQWUDomR GH ȝPRO/ 2 IiUPDFR $ p GHQRPLQDGR DJRQLVWD WRWDO

SURGX]LQGRUHVSRVWDPi[LPDFRP ȝPRO/

')È 50 $& 26 $ 17 $* 21 , 67 $ 6

2 V DQWDJRQLVWDV GLYLGHPVH DQWDJRQLVWDV GH UHFHSWRUHV H

DQWDJRQLVWDVVHPUHFHSWRUHVFRPRREVHUYDGRQDHVWUXWXUD DEDL[R

Interação fármaco-receptor parte 2, Notas de aula de Farmacologia

Documentos relacionados

Pré-visualização parcial do texto

Baixe Interação fármaco-receptor parte 2 e outras Notas de aula em PDF para Farmacologia, somente na Docsity!

)$ 50 $& 2 / 2 *,$  $ 8 /$   )$ 50 $& 2 ', 1 Æ 0 ,&$

, 17 ( 5 $d 2 )È 50 $& 2  5 (&( 3725

$)È 50 $& 26 $* 21 , 67 $ 6 ($ 17 $* 21 , 67 $ 6

Ɣ DJRQLVWDV

FRQFHQWUDomR GH  ȝPRO/ 2 IiUPDFR $ p GHQRPLQDGR DJRQLVWD WRWDO 

SURGX]LQGRUHVSRVWDPi[LPDFRP ȝPRO/

')È 50 $& 26 $ 17 $* 21 , 67 $ 6

2 V DQWDJRQLVWDV GLYLGHPVH DQWDJRQLVWDV GH UHFHSWRUHV H

DQWDJRQLVWDVVHPUHFHSWRUHVFRPRREVHUYDGRQDHVWUXWXUD DEDL[R

)$ 50 $& 2 / 2 *,$ $ 8 /$ )$ 50 $& 2 ', 1 Æ 0 ,&$

, 17 ( 5 $d 2 )È 50 $& 2 5 (&( 3725

$)È 50 $& 26 $* 21 , 67 $ 6 ($ 17 $* 21 , 67 $ 6

Ɣ DJRQLVWDV

FRQFHQWUDomR GH ȝPRO/ 2 IiUPDFR $ p GHQRPLQDGR DJRQLVWD WRWDO

SURGX]LQGRUHVSRVWDPi[LPDFRP ȝPRO/

')È 50 $& 26 $ 17 $* 21 , 67 $ 6

2 V DQWDJRQLVWDV GLYLGHPVH DQWDJRQLVWDV GH UHFHSWRUHV H

DQWDJRQLVWDVVHPUHFHSWRUHVFRPRREVHUYDGRQDHVWUXWXUD DEDL[R