Small Protein Structure
Determination
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Cryo-EM for Small Protein Structural Determination: Services by Creative Biostructure, Slides of Biology
Cryo-electron microscopy (cryo-EM) is an advanced technique in structural biology for studying small proteins at the atomic level. Creative Biostructure offers high-resolution imaging and three-dimensional reconstruction services for small proteins using improved sample preparation, binding agents, electron dose optimization, defocus variation, energy filter, contrast enhancement, and phase plate. The advantages include time-saving, cost-effective, and comparable resolution to traditional X-ray crystallography.
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2019/2020
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Small Protein Structure
Determination
Cryo-electron microscopy (cryo-EM) is a form of transmission
electron microscopy (TEM) where biological samples are
studied at cryogenic temperatures. It is becoming a more and
more important technique in the field of structural biology, as
has been manifested by many once hard-to-determine
macromolecular structures. With the rapid advancement of
both hardware and software, the resolution of cryo-EM maps is
improving steadily. In some cases, near-atomic resolution had
been obtained, including those of viruses, ribosomes,
mitochondria, ion channels, and enzyme complexes as small as
150 kD.
The advantages of using our EM platform for the structure
determination of proteins with small molecular weight include
sample-saving, fast turnaround time, and cost-effective. Creative
Biostructure promises to work closely with our customers to provide
tailored cryo-EM strategies for determining the structure of
biologically or structurally important small proteins, with a resolution
comparable to traditional X-ray crystallography techniques.