WGU Pathophysiology D236 Study Guide Complete, Exams of Advanced Education

WGU Pathophysiology D236 Study Guide Complete

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2025/2026

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WGU Pathophysiology D236
Describe how your body responds to an infection.
T cells produce cytokines, which stimulate B cells. B cells produce antibodies.
Identify role of DNA changes in congenital abnormalities.
Mutations in genes or chromosomal abnormalities
How does development disrupts congenital abnormalities?
Alterations of DNA
Describes factors that disrupt homeostasis and how disruptions affect wellbeing.
(ex) Fluid and electrolyte shifts can cause n/v or dysrhythmias.
Explain RAAS
Renin-angiotensin-aldosterone system
1. Reduce blood flow causes kidneys to release renin
> produce angiotensin I > converts angiotensin I to angiotensin II > vasoconstriction > release
aldosterone > kidneys conserve sodium and water > Result less water lost in urine and blood
pressure maintained.
DKA
increased anion gap, decreased HCO3
How do kidneys compensate for alkalosis
retain H and excrete HCO3
Untreated acidosis leads to an increase in which electrolyte?
Potassium
West Nile Virus
Transmitted through the bite of an infected mosquito. Severe signs and symptoms; high fever,
headache and stiff neck
Lyme disease
Tick-borne disease caused by the spirochete Borrelia burgdorferi.
Erythema infectiosum
a febrile upper respiratory illness in a child followed by the sudden appearance of red, flushed
cheeks, "fifth disease"
Obesity ad diabetes are risk factors for having a child with _____.
Spina bifida
Trousseau's sign
arm/carpal spasm associated with hypocalcemia
Cause and sign of spina bifida
results from failure of neural tube to close. sign - fluid filled sac on lower back.
hemophilia is more common in
males
Prenatal exposure to alcohol includes
ND-PAE, decreased brain function, FAS
Connective vs muscle tissue disorders
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WGU Pathophysiology D

Describe how your body responds to an infection. T cells produce cytokines, which stimulate B cells. B cells produce antibodies. Identify role of DNA changes in congenital abnormalities. Mutations in genes or chromosomal abnormalities How does development disrupts congenital abnormalities? Alterations of DNA Describes factors that disrupt homeostasis and how disruptions affect wellbeing. (ex) Fluid and electrolyte shifts can cause n/v or dysrhythmias. Explain RAAS Renin-angiotensin-aldosterone system

  1. Reduce blood flow causes kidneys to release renin > produce angiotensin I > converts angiotensin I to angiotensin II > vasoconstriction > release aldosterone > kidneys conserve sodium and water > Result less water lost in urine and blood pressure maintained. DKA increased anion gap, decreased HCO How do kidneys compensate for alkalosis retain H and excrete HCO Untreated acidosis leads to an increase in which electrolyte? Potassium West Nile Virus Transmitted through the bite of an infected mosquito. Severe signs and symptoms; high fever, headache and stiff neck Lyme disease Tick-borne disease caused by the spirochete Borrelia burgdorferi. Erythema infectiosum a febrile upper respiratory illness in a child followed by the sudden appearance of red, flushed cheeks, "fifth disease" Obesity ad diabetes are risk factors for having a child with _____. Spina bifida Trousseau's sign arm/carpal spasm associated with hypocalcemia Cause and sign of spina bifida results from failure of neural tube to close. sign - fluid filled sac on lower back. hemophilia is more common in males Prenatal exposure to alcohol includes ND-PAE, decreased brain function, FAS Connective vs muscle tissue disorders

Connective- RA, Scleroderma, Lupus Muscle - MS, Muscular dystrophy, Myasthenia Gravia Describe Lupus Inflammatory disorder characterized by joint pain and butterfly rash Describe Myasthenia Gravis It is an autoimmune disorder where antibodies attack own Ach receptors. This causes weakness of skeletal muscles over the course of the day, along with ptosis, double vision, and difficulty swallowing. dermatitis inflammation of the skin eczema noninfectious, inflammatory skin disease characterized by redness, blisters, scabs, and itching decubitus ulcer sore caused by lying down for long periods of time Fungal infections superficial, localized skin conditions or deep tissue infections caused by exposure to spores may or may not be transmitted benign neoplasm noncancerous growths, stationary, distinct borders malignant neoplasm uncontrolled new tissue growth, irregular borders, spreads Osteoporosis The loss of bone mass often due to age, causing the bones to become porous, brittle, and easily fractured. osteomalacia disease marked by softening of the bone caused by calcium and vitamin D deficiency myoglobin red pigment that stores oxygen in muscle cells Bursa fluid-filled sac that allows for easy movement of one part of a joint over another Rickets a vitamin D deficiency in children, resulting in soft bones Degenerative disk disease A condition in which an intervertebral disk loses its normal structural integrity as a result of wear and tear, acute or repeated injuries or aging Paget disease Chronic inflammation of bones, resulting in thickening and softening of bones, that can occur in any bone but most commonly affects the long bones of the legs, the lower spine, the pelvis, and the skull communiuted fracture splintered into many pieces Three types of skin cancer

cerebral contusion the bruising of brain tissue as the result of a head injury that causes the brain to bounce against the rigid bone of the skull; symptoms: ringing in ears, severe headache, n/v. TIA vs CVA TIA = -result when a cerebral artery is temp blocked and decreases blood flow to brain Stroke= artery completely blocked leading to death of brain and permanent loss of certain functions multiple sclerosis A chronic, irreversible disease of the central nervous system marked by damage to the myelin sheath. Plaques occur in the brain and spinal cord causing tremor, weakness, incoordination, paresthesia, and disturbances in vision and speech aneurysm ballooning of a weakened portion of an arterial wall thrombus vs embolus Thrombus = clot in arteries embolus = dislodged traveling clot in arteries, blocks blood flow Artherosclerosis Hardening and narrowing of the arteries due to buildup of cholesterol plaques 1.endothelial injury 2.foam cell formation 3.fatty streak formation angina pectoris chest pain, which may radiate to the left arm and jaw, that occurs when there is an insufficient supply of blood to the heart muscle myocardial infarction the occlusion of one or more coronary arteries caused by plaque buildup (heart attack) endocaritis inflammation of the inner lining of the heart peridcarditis inflammation of the pericardium (sack surrounding heart) benign vs malignant hypertension benign - "essential hypertension", chronic vascular damage due to sodium retention. malignant - acute vascular damage due to renin release communicable disease A disease that can be spread from one person or species to another. infectious disease A disease that is caused by a pathogen and that can be spread from one individual to another. myocardial infarction causes damage to arteries of : brain, retina, heart, kidneys. what is expected in right sided heart falure JVD what characterizes hypertensive crisis

systolic BP > 180 types of anemia

  • Aplastic (decreased or missing RBC production)
  • Iron Deficiency
  • Folic Acid Deficiency
  • Vitamin B12 Deficiency/Pernicious
  • Hemolytic (breakdown of RBCs faster than produced)
  • Sickle Cell (RBCs die too early, shortage of RBCs) Where does cancer originate from in leukemia? bone marrow CD4 cells Helper T cells that mature in thymus that active B cells to create immunity Hodgkin's lymphoma distinguished from other lymphomas by the presence of large, cancerous lymphocytes known as Reed-Sternberg cells Lymphocytosis abnormal increase in lymphocytes, asymptomatic Stable angina predictable and consistent pain that occurs on exertion and is relieved by rest and/or nitroglycerin Upper respiratory tract infection common cold, laryngitis, croup, pharyngitis, rhinitis, sinusitis, and tonsillitis lower respiratory tract infection pneumonia, bronchitis, tuberculosis conditions that lead to COPD smoking, asthma, dust, chemicals, genetics pnemonia an inflammation in the lung caused by infection from bacteria, viruses, fungi, or parasites, or resulting from aspiration of chemicals. Hear crackles and rhonchi. Asthma treatment resistant bronchospasm, same category of COPD pneumothorax air in the pleural cavity caused by a puncture of the lung or chest wall cor pulmonale right-sided heart failure arising from chronic lung disease Coal Worker's Pneumoconiosis Carbon dust, seen in coal miners. Massive exposure leads to diffuse fibrosis('black lung') common characteristics of chronic digestive system disorders (Celiac, Chron's, Colitis...) Abdominal pain, weight loss, changes in urination/bowel movements, bleeding, diarrhea, n/v.... common characteristics of acute digestive system disorders (GERD, IBS, Hiatal hernia...) Abd pain, bleeding, bloating, diarrhea, heartburn, n/v pyelonephritis Inflammation of the renal pelvis and kidney; caused by bacterial infection (commonly E. Coli) glomerulonephritis inflammation of the glomeruli in the kidneys from injury or illness

risk factors for bladder cancer Smoking**, occupational exposure to dyes (benzenes, aromatic amines), Hx of gross hematuria, >40 y/o, hx of urologic disorder, Hx of irritative voiding symptoms, Hx of UTI, analgesic abuse, history of pelvic irradiation See 50 more