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Mark your answers on the Answer Sheet.
I Choose a word from each of the following sets to fill in the numbered blank spaces in the text.
13. ——— ( line 3 ) a) motives b) reasons c) causes d) symptoms 14. ——— (line 8) a) Because b) Perhaps c) Curiously d) Although 15. ——— (line 14) a) will b) can c) must d) shall 16. ——— (line 18 ) a) respect b) place c) spite d) stead 17. ——— (line 23) a) out b) in c) up d) on 18. ——— (line 26) a) so b) because c) but d) somehow 19. ——— (line 37 ) a) some b) unknown c) any d) one 20. ——— (line 43) a) from b) on c) with d) over
II What do the underlined words mean in the text?
21. “sketchy” (line 11) a) unclear b) misleading c) reliable d) irrelevant 22. “peers” (line 40) a) children of the same age b) other children suffering from autism c) friends who do not suffer from autism d) normal children
A genetic mutation that increases the risk of blood clotting raises the risk of sudden cardiac death in early middle age, researchers in Finland report. The variation, which makes blood stickier, was more than twice as common among men who experienced sudden cardiac death before age 55 than in men who died from other causes, according to study findings published in the August 21st issue of Circulation: Journal of the American Heart Association. The mutation was also more common in men who died from a heart attack or who died after a heart artery became blocked.
Sudden cardiac death occurs when a person's heart abruptly stops functioning, and coronary artery disease--the clogging of arteries supplying the heart with blood--is the most common cause. But sudden cardiac death sometimes occurs in apparently healthy people without any symptoms of heart disease. **We** have identified a new risk factor increasing markedly the risk of fatal heart attack in early middle age,'' the study's lead author, Dr. Jussi Mikkelsson of the University of Tampere, told Reuters Health.Such an event is usually unexpected and occurs in an individual without previous symptoms of heart disease.'' In the study, the researchers reviewed the autopsies of 700 mostly middle-aged Finnish men who died suddenly outside of the hospital. They determined whether the men had a variation called HPA-2 Met, which affects blood components called platelets that are involved in blood clotting.
Compared with men who died from causes unrelated to heart disease, those who died from a heart attack were twice as likely to carry the gene mutation, the report indicates. Men who died of an artery blockage called coronary thrombosis were 2.6 times more likely to have the variation. The link between the variation and heart-related death was particularly strong in men younger than 55, according to Mikkelsson's team. In younger men, the variation was 2.2 times more common in those who had experienced sudden cardiac death. Among all men younger than 55, the variation was present in about 59% who had died from a heart attack and 70% who had died from coronary thrombosis, but it was found in only about 20% of younger men who died from causes other than heart disease.
The findings will not have an immediate effect in the clinic, but they may have an impact within the next decade, Mikkelsson noted. The Finnish researcher speculated that someday doctors may run a panel of genetic tests on patients in their 40s who have a family history of heart disease. ``The results of this panel would thus make it easier to predict the risk of heart disease and guide therapeutic decisions in the primary prevention of heart disease,'' Mikkelsson said.
Studies are under way to see whether drugs that reduce the risk of blood clots, such as aspirin, may lower the risk of heart disease in people who carry the genetic variation, the researcher pointed out. “However,” he added, ``it is possible that aspirin is not enough to lower the risk.'' Mikkelsson said that there are several drugs--both on the market and in clinical trials--that specifically target the platelet receptor affected by the gene variation. Also, he suggested, people with the variation might be able to reduce their risk of heart disease by controlling traditional risk factors for heart disease, such as smoking, diet, exercise and high blood pressure.
Mark your answers on the Answer Sheet.
I Choose a word from each of the following sets to fill in the numbered blank spaces in the text.
36. ——— ( line 5 ) a) and b) so c) but d) rather 37. ——— (line 8 ) a) of b) from c) with d) to 38. ——— (line 11) a) mostly b) hardly c) rarely d) particularly 39. ——— (line 15 ) a) ranging b) living c) growing d) differing 40. ——— (line 23 ) a) asking b) need c) treating d) necessity 41. ——— (line 25) a) more b) also c) repeatedly d) again 42. ——— (line 30 ) a) provoke b) develop c) cause d) grow 43. ——— (line 35 ) a) avoid b) stop c) prevent d) reduce